研究業績

*責任著者 Corresponding author

2021以降

- - Davidson L, Rouvière JO, Sousa-Luís R, Nojima T, Proudfoot NJ, Jensen TH, and West S*, DNA-directed termination of mammalian RNA polymerase II. Genes and Development 2024
    DOI:10.1101/gad.351978.124　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  - Wilton J, de Mendonca FL, Pereira-Castro I, Tellier M, Nojima T, Costa AM, Freitas J, Murphy S, Oliveira MJ, Proudfoot NJ, and Moreira A*, Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages.Frontiers in Immunology 2023
    DOIhttps://doi.org/10.3389/fimmu.2023.1182525　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　　
  - Iannone C, kainov Y, Zhuravskaya A, Hamid F, Nojima T, and Makeyev EV*, PTBP1-activated co-transcriptional splicing controls epigenetic status of pluripotent stem cells, Molecular Cell, 2023
    DOI https://doi.org/10.1016/j.molcel.2022.12.014
  - Tellier M*, Zaborowska J, Neve J, Nojima T, Hester S, Fournier M, Furger A, and Murphy S*, CDK9 and PP2A regulate RNA polymerase Ⅱ transcription termination and coupled RNA maturation, EMBO reports, 2022
  - Nojima T* and Proudfoot NJ*, Mechanism of lncRNA biogenesis as revealed by nascent transcriptomics. Nature Reviews Molecular Cell Biology, 2022, (Review Article), DOIhttps://doi.org/10.1038/s41580-021-00447-6
  - Sousa-Luis R, Dujardin G, Zukher I, Kimura H, Carmo-Fonseca M*, Proudfoot NJ*, and Nojima T*, POINT Technology Illuminates the Processing of Polymerase-Associated Intact Nascent Transcripts. Molecular Cell, vol. 81, pp. 1935-1950, 2021
    Mol Cell 誌でハイライトされました。
  - Larke MSC, Schwessinger R, Nojima T, Telenius J, Beagrie RA, Downes DJ, Oudelaar AM, Truch J, Graham B, Bender MA, Proudfoot NJ, Higgs DR*, and Hughes JR*, Enhancers predominantly regulate gene expression during differentiation via transcription initiation, Molecular Cell, vol. 81, pp. 983-997, 2021

2016~2020

- - Tellier M, Zaborowska J, Caizzi L, Mohammad E, Velychko T, Schwalb B, Ferrer-Vicens I, Blears D, Nojima T, Cramer P and Murphy S*, CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation, Nucleic Acid Research, vol. 48, pp. 7712–7727, 2020
  - Gregersen LH, Mitter R, Ugalde AP, Nojima T, Proudfoot NJ, Agami R, Stewart A and Svejstrup JQ*, SCAF4 and SCAF8, mRNA Anti-terminator Proteins, Cell, vol. 177, pp. 1797-1813, 2019
  - Kamieniarz-Gdula K*, Gdula MR, Panser K, Nojima T, Monks J, Wiśniewski JR, Riepsaame J, Brockdorff N, Pauli A* and Proudfoot NJ*, Selective roles of vertebrate PCF11 in premature and full-length transcript termination, Molecular Cell, vol.74, pp. 158-172, 2019
  - Nojima T *, Tellier M, Foxwell J, Rebeiro de Almeida C, Tan-Wong SM, Dhir S, Dhir A, Murphy S* and Proudfoot NJ*, Deregulated expression of lncRNA through loss of SPT6 induces R-loop, DNA replication stress and cellular senescence, Molecular Cell, vol. 72, pp. 970-984, 2018b
  - Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ* and Carmo-Fonseca M*, RNA polymerase II phosphorylated on CTD serine 5 interacts with the spliceosome during co-transcriptional splicing, Molecular Cell, vol. 72, pp. 369-379, 2018a
    日本語解説　https://first.lifesciencedb.jp/18858
  - Dhir A*, Dhir S, Borowski L, Jimenez L, Teitell M, Rotig A, Crow YJ, Rice GI, Duffy D, Tamby C, Nojima T, Munnich A, Schiff M, Ribeiro de Almeida C, Rehwinkel J, Dziembowski A, Szczesny R, and Proudfoot NJ, Mitochodrial double-stranded RNA triggers antiviral signaling in human, Nature, vol. 580, pp. 238-242, 2018
  - Bauer D, Tellier M, Martinez-Alonso M, Nojima T, Proudfoot NJ, Murphy S and Fodor E*, Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription, Cell Reports, vol. 23, pp. 2119-2129, 2018
  - Schlackow M, Nojima T*, Gomes T, Dhir A, Carmo-Fonseca and Proudfoot NJ*, Distinctive patterns of transcription and RNA processing for human lincRNA, Molecular Cell, vol. 65, pp. 25-38, 2017
    日本語解説　https://first.lifesciencedb.jp/15043
    Mol Cell 誌でハイライトされました。
  - Ohe K, Yoshida M, Nakano-Kobayashi A, Hosokawa M, Sako Y, Sakuma M, Okuno Y, Usui T, Ninomiya K, Nojima T, Kataoka N and Hagiwara M*, RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia, RNA, vol. 23, pp. 1393-1403, 2017
  - Nojima T*, Gomes T, Carmo-Fonseca M and Proudfoot NJ*, Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide, Nature Protocols, vol. 11, pp. 413-428, 2016

2011~2015

- - Nojima T, Gomes T Grosso AR, Kimura H, Dye MJ, Dhir S, Carmo-Fonseca M* and Proudfoot NJ*, Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing, Cell, vol. 161, pp. 526-540, 2015
    日本語解説 https://first.lifesciencedb.jp/10127
    Cell誌の表紙でハイライトされました。 Cell, volume 161 issue 3
    Nature Methods誌でハイライトされました。 https://www.nature.com/articles/nmeth.3467
  - Yoshida M, Kataoka N, Miyauchi M, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T and Hagiwara M*, Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia, Proceedings of the National Academy of Science USA (PNAS), vol. 112, pp. 2764-2769, 2015
  - Nojima T, Dienstbier M, Murphy S, Proudfoot N and Dye M, Definition of RNA Polymerase II CoTC Terminator Elements in the Human Genome, Cell Reports, vol. 3, pp. 1080-1092, 2013

2010以前

- Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto T, Kawaguchi Y, Kataoka N and Hagiwara M, Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing, Nucleic Acid Research, vol. 37, pp. 6515-6527, 2009
- Nojima T, Hirose T, Kimura H and Hagiwara M, The interaction between cap-binding complex and REF is required for intronless mRNA export, Journal of Biological Chemistry, vol. 282, pp. 15645-15651, 2007
- Kaida D, Motoyoshi M, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S and Yoshida M*, A novel cell cycle inhibitor spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature Chemical Biology, vol. 3, pp. 576-583, 2007